Profiles of Inspiration4: Hayley Arceneaux set to be the youngest American in orbit

Hayley Arceneaux floats in a zero-g plane while holding a banner for St. Jude Children’s Research Hospital. Credit: Inspiration4 / John Kraus
The first person announced to join Jared Isaacman for the Inspiration4 mission was Hayley Arceneaux, a childhood cancer survivor and current St. Jude Children’s Research Hospital employee.
This is the second of four stories profiling the Inspiration4 crew, which are expected to launch in a SpaceX Crew Dragon capsule atop a Falcon 9 rocket from Launch Complex 39A at NASA’s Kennedy Space Center as early as Sept. 15, 2021.

The whole Inspiration4 crew. From left to right: Chris Sembroski, Sian Proctor, Jared Isaacman and Hayley Arceneaux. Credit: Inspiration4 / John Kraus
The Inspiration4 mission consists of four non-professional astronauts — Jared Isaacman, a self-starter who dreamed of flying and going to space his entire life; Hayley Arceneaux, a childhood cancer survivor and now a St. Jude physician assistant; Sian Proctor, a geoscientist, explorer and science communication specialist; and Chris Sembroski, an Iraq war veteran and current Lockheed Martin engineer.
When they launch, Arceneaux will be the chief medical officer of the three-day mission into Earth orbit, and represents the mission pillar of hope. During the flight the crew is expected to perform a multitude of human health and medical research.
Arceneaux was born in Baton Rouge, Louisiana, in 1991. At the age of 10, she was diagnosed with osteosarcoma, a type of bone cancer. Her family sent her to St. Jude Children’s Research Hospital for treatment and care, which included chemotherapy and a limb-saving surgery that replaced her knee and placed a titanium rod in her left thigh bone.
After her treatment, she eventually went on to earn a degree in Spanish in 2014 and obtained a physician assistant degree in 2016. She now works for St. Jude Children’s Research Hospital as a licensed physician assistant.

Arceneaux following her jet arrival in Florida less than a week before the Inspiration4 launch. Credit: Inspiration4 / John Kraus
She will be joining her three other crewmembers aboard a SpaceX Crew Dragon spacecraft as part of the first all-private civilian astronaut crew to go into low Earth orbit. In early 2021, the mission’s sponsor, Jared Isaacman, offered one of the seats to a representative to St. Jude, which immediately recommended Arceneaux.
“I will be the the youngest American to go to space but what I am really excited about is I will be the first pediatric cancer survivor to got to space and the first person with an internal prosthesis as I have a titanium rod in my leg from where they saved my leg when I had cancer treatment,” Arceneaux said to The View during a teleconference interview in July. “I’m really excited to show all these kids going through cancer treatment what they can do too.”
The entirety of the Inspiration4 mission is being funded by Isaacman as a fundraiser for St Jude Children’s Research Hospital. The goal is to raise $200 million for the organization.
Arceneaux along with her fellow crew members completed astronaut training and flight training in military jet trainers. Following training in jets, she received her callsign — Nova.
This is the second of four stories profiling the Inspiration4 crew. Click here for the story about 51-year-old Sian Proctor, a geoscientist, explorer and science communication specialist who represents the space mission’s pillar of prosperity.
Video courtesy of St. Jude Children’s Research Hospital
Video courtesy of Orbital Velocity
Michael McCabe
A native of Lonedell, Missouri, Michael McCabe is a former Long Island firefighter and emergency medical technician. He is a non-active Florida EMT with 20 years of fire rescue experience. He is also a lifelong science fiction and space enthusiast. At the age of 10, he watched in his school classroom as the Space Shuttle Challenger exploded in 1986. In 2008, he moved to the Sunshine State and works as a private tour guide at Kennedy Space Center Visitor Complex for a private company based in Orlando. McCabe has been a fan of SpaceFlight Insider since our inception in 2013. He reached out to ask how he could assist our efforts to spread space flight awareness. Shortly thereafter, he was welcomed into our expanding team.